Dr. Velasco explains research with cannabinoids for cancer treatment

Dr Guillermo Velasco from the Complutense University in Madrid talks about the upcoming independent clinical trials that are due to take place in Spain in 2018. The trials are being funded by donations from the Medical Cannabis Bike Tour, a non-profit organization that raises money through sponsorship of its annual bike ride.

Dr Velasco describes how the clinical trials will be conducted (based on a study of 30 patients), using the cannabinoids, Tetrahydrocannabinol (THC) and cannabidiol (CBD).
Dr Velasco will be overseeing the trials that are being conducted with the support of the Spanish Group on Neuro Oncological Investigation, GEINO. Current scientific evidence supports that cannabis derivatives may provide relief to patients suffering from gliomas.

Published studies have demonstrated that the active principles of cannabis promote cancer cell death. Pre-clinical work performed over the past few years by the Complutense University team, has proved that the active principles of cannabis have anticancer activity in animal and cell models of glioma.

Performing experiments with cannabinoidsRealizando experimentos con cannabinoides

Research Cannabinoids Cancer Remission

Quick update on the work the team in Madrid are involved in, by the words of Prof. Guillermo.

We have done in vitro experiments with Glioma initiating cell and have found that the combination of cannabinoids with other anticancer agents [and specifically with inhibitors of the growth factor midkine (MK) and the Anaplasic lymphoma kinase (ALK)] can eliminate these cells. This results could be important since the population of GICs is responsible for the high resistance to conventional therapies that exhibit the patients with Glioblastoma (the most frequent class of brain tumor).

– At the moment we are performing experiments in mice carrying brain tumors to test the effect of the combination of cannabinoids and ALK inhibitors in animal models of glioma and also melanoma.

This year we hope to achieve results that confirm these observations in vitro and in animal models of glioma and also investigate the mechanism of action of cannabinoids in glioma, particularly how activation of autophagy is required for the anticancer activity of cannabinoids.
We are also analyzing the effect of cannabinoid combinations in melanoma models in vitro and also in animal models of melanoma.

(In layman’s words, we expect to find results that support the utilization of cannabinoids in novel therapies to fight glioma and melanoma)

Thank you again for your support and please let us know if you require additional information.

All the best,


Also below is a pdf presentation of the work carried out by the team:

Performing experiments with cannabinoids. medical cannabis bike tour 2014